反应详情

To a solution of (2S)-2-[(tert-butoxycarbonyl)amino]-8-oxodecanoic acid in dioxane were added Py (1 eq.), Boc2O (1.3 eq) and ammonium bicarbonate (1.26 eq.). The reaction mixture was stirred at RT for 72 hours and then the solvent was evaporated under reduced pressure. The resulting crude was diluted with EtOAc and washed with H2O, 1 N HCl and brine. The organic phase was dried (Na2SO4) and concentrated under reduced pressure to yield a white powder which was as such in the next step. MS (ES) C15H28N2O4 requires: 300, found: 301 (M+H+).

1. customthe solvent was evaporated under reduced pressure
2. additionThe resulting crude was diluted with EtOAc
3. washwashed with H2O, 1 N HCl and brine
4. dry with materialThe organic phase was dried (Na2SO4)
5. concentrationconcentrated under reduced pressure
6. customto yield a white powder which