反应详情

A mixture of (2S)-2-[(tert-butoxycarbonyl)amino]-8-oxodecanoic acid (1 eq), TBTU (1.2 eq), HOBt (0.2 eq) and DIPEA (5 eq) in DMF was stirred at RT for 5 min; then added N-hydroxynaphthalene-2-carboximidamide was added and the mixture was stirred at RT for 20 min, after which time the mixture was warmed to 110° C. for 2 h. The solvent was removed under reduced pressure and the resulting crude used as such in the next step. MS (ES) C26H33N3O4 requires: 451, found: 452 (M+H+).

1. stirringthe mixture was stirred at RT for 20 min
2. temperatureafter which time the mixture was warmed to 110° C. for 2 h
3. customThe solvent was removed under reduced pressure