反应详情

Four point three grams (32 mmol) of aluminum chloride was placed into 30 milliliter of 1,2-dichloroethane and a solution made by dissolving 2.0 g (25 mmol) of acetyl chloride, subsequently 5.0 g (21 mmol) of 4-bromo biphenyl into 20 milliliter of 1,2-dichloroethane was added while cooling with ice. The mixed solution was stirred as it is while cooling with ice for 4 hours. After completion of the reaction, adding water and an extraction was carried out using dichloro-methane. Further, washing with water, dried with the use of sodium sulfate. Removing the solvent by distillation, 5.9 g of crude 1-(4′-bromo-biphenyl-4-yl)-ethanone was obtained.

1. additionwas added
2. temperaturewhile cooling with ice
3. temperaturewhile cooling with ice for 4 hours
4. customAfter completion of the reaction
5. extractionan extraction
6. washFurther, washing with water
7. dry with materialdried with the use of sodium sulfate
8. customRemoving the solvent
9. distillationby distillation