反应详情

Dissolving crude 3,5-diphenyl-2-amino-pyridine obtained and 5.5 g (20 mmol) of 2,4′-dibromo acetophenone into 80 milliliter of ethanol, adding 3.0 g of sodium hydrogen carbonate, the resultant suspension was refluxed under heating for 7 hours. After completion of the reaction, separation with filtration was carried out and resultant crystals were washed with water and methanol, thereby obtaining 6.9 g of 2-(4-bromo-phenyl)-6-phenyl-imidazo [1,2-a] pyridine (yield: 82%).

1. customobtained
2. temperatureunder heating for 7 hours
3. customAfter completion of the reaction, separation
4. filtrationwith filtration
5. washresultant crystals were washed with water and methanol