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HRID251857

反应详情

EQUATION

反应方程式

HRID 251857 的结构方程式

REACTANTS

反应物

3
结构：NCc1ccc(Cl)cc1Cl
HCID1485

Benzenemethanamine, 2,4-dichloro-

C7H7Cl2N

结构：F[P-](F)(F)(F)(F)F.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1
HCID2724699

PyBOP

C18H28F6N6OP2

结构：O=C(O)c1cn(C2CC2)c2c(Cl)c(F)c(F)cc2c1=O
HCID9835941

8-Chloro-1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

C13H8ClF2NO3

PRODUCTS

生成物

1
结构：O=C(NCc1ccc(Cl)cc1Cl)c1cn(C2CC2)c2c(Cl)c(F)c(F)cc2c1=O
HCID57780978

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

15.0 g of 8-chloro-1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (for preparation see DE 3420743 or Y. Kimura et al., J. Med. Chem. (1994) 37:3344) are dissolved in 500 ml of DMF and 31.3 g of PyBOP and 10.6 g of 2,4-dichlorobenzylamine are added. After a day the solvent is removed and the residue is purified by flash chromatography on silica gel (toluene/ethyl acetate 95:5).

WORKUP

后处理

  1. customAfter a day the solvent is removed
  2. customthe residue is purified by flash chromatography on silica gel (toluene/ethyl acetate 95:5)