Sodium Azide → HCID 131728611, compound

HRID 251858Notes

Reaction equation

HRID 251858 reaction equation
[Cl:1][CH2:2][C:3]([N:5]1[C@@H:10]([CH3:11])[CH2:9][N:8]([C:12]2[C:21]([O:22][CH3:23])=[C:20]3[C:15]([C:16](=[O:39])[C:17]([C:27]([NH:29][CH2:30][C:31]4[CH:36]=[CH:35][C:34]([Cl:37])=[CH:33][C:32]=4[Cl:38])=[O:28])=[CH:18][N:19]3[CH:24]3[CH2:26][CH2:25]3)=[CH:14][C:13]=2[F:40])[CH2:7][C@H:6]1[CH3:41])=[O:4].[N-:42]=[N+:43]=[N-:44].[Na+]>CN(C)C=O>[ClH:1].[N:42]([CH2:2][C:3]([N:5]1[CH:6]([CH3:41])[CH2:7][N:8]([C:12]2[C:21]([O:22][CH3:23])=[C:20]3[C:15]([C:16](=[O:39])[C:17]([C:27]([NH:29][CH2:30][C:31]4[CH:36]=[CH:35][C:34]([Cl:37])=[CH:33][C:32]=4[Cl:38])=[O:28])=[CH:18][N:19]3[CH:24]3[CH2:26][CH2:25]3)=[CH:14][C:13]=2[F:40])[CH2:9][CH:10]1[CH3:11])=[O:4])=[N+:43]=[N-:44]

Participants

4

Reactant 2

HCID 33557Sodium AzideHCID 59028001HCID 59028001, compound

Product 1

HCID 131728611HCID 131728611, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

50.0 mg of the compound of Example 80A and 15.6 mg (0.24 mmol) of sodium azide are stirred in 3 ml of N,N-dimethylformamide in a closed reaction vessel at 90° C. over night. After fine purification by preparative RP-HPLC (Method 6) 46 mg of the target compound are obtained.

Workup

  1. customAfter fine purification by preparative RP-HPLC (Method 6) 46 mg of the target compound
  2. customare obtained

Sources & evidence

ORD record
ord-03749ae014754cee9f5c13ae3fb77111
Source dataset
uspto-grants-2011_01
Patent number
US07867992B2

Reaction notes

Loading…