反应详情

(R)-2-(6,8-Dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenylamine (enantiomer B, preparation as described in WO2004085404), 4-nitrophenyl chloroformate and methylaminoacetaldehyde dimethyl acetal were reacted analogously to example 40, and the resulting intermediate (85 mg) was subsequently cyclized with a mixture of water (1 ml) and 10% hydrochloric acid (3.2 ml). Workup and purification were analogous to example 40. 65 mg of the title compound were isolated.

1. customWorkup and purification