反应详情

A mixture of ethyl-phenyl-amine (4.15 mL, 33 mmol), allyl bromide (4.3 mL, 1.5 eq.) and K2CO3 (9.1 g, 2.0 eq.) in acetone (50 mL) was heated at reflux for overnight. After cooling to room temperature, the reaction mixture was diluted with water (50 mL) and EtOAc (100 m). The separated organic phase was dried over Na2SO4, filtered and concentrated and the product was purified by chromatography (10% EtOAc/hexanes) to give allyl-ethyl-phenyl-amine (5.32 g, 100%).

1. temperaturewas heated
2. temperatureat reflux for overnight
3. dry with materialThe separated organic phase was dried over Na2SO4
4. filtrationfiltered
5. concentrationconcentrated
6. customthe product was purified by chromatography (10% EtOAc/hexanes)