Hydrochloric Acid → 861451-21-0

HRID 252376Notes

Reaction equation

HRID 252376 reaction equation
[CH3:1][C:2]([C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1)([CH3:7])[C:3]([O:5][CH3:6])=[O:4].[ClH:14]>CO.[Pt](=O)=O>[ClH:14].[CH3:7][C:2]([CH:8]1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1)([CH3:1])[C:3]([O:5][CH3:6])=[O:4]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 57421204HCID 57421204, compound

Product 1

HCID 57421202861451-21-0

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 887MethanolSolvent2×

Procedure

0.115 g of methyl 2-methyl-2-pyridin-4-ylpropionate [79757-27-0] are dissolved in 5 ml of methanol in an autoclave. The solution is admixed with 0.35 ml of 1.2M HCl in methanol and 0.012 g of platinum(IV) oxide and the reaction mixture is hydrogenated at 4 bar and 23° C. over 46 hours. The catalyst is filtered off through Hyflo and the filtrate is concentrated by evaporation. The title compound is obtained as a light brown residue. Rf=0.05 (200:20:1 dichloromethane-methanol-25% conc. ammonia).

Workup

  1. filtrationThe catalyst is filtered off through Hyflo
  2. concentrationthe filtrate is concentrated by evaporation

Sources & evidence

ORD record
ord-4eaaa427b3a24109b93731c8ee7f8912
Source dataset
uspto-grants-2011_01
Patent number
US07868036B2

Reaction notes

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