反应详情

A solution of 1.57 g of 3,6-diethoxy-2-{2-[8-(2-methoxyethoxy)naphthalen-2-ylmethyl]-3-methylbutyl}-2,5-dihydropyrazine in 14 ml of acetonitrile at room temperature is admixed with 14 ml of 1N HCl. After 30 minutes, the reaction mixture is poured into a stirred mixture of 15 ml of saturated aqueous sodium bicarbonate solution and 15 g of ice, and the mixture is extracted with dichloromethane (3×). The combined organic phases are washed with water (3×), dried with sodium sulphate and concentrated by evaporation. The crude title compound is identified on the basis of the Rf value from the residue.

1. customat room temperature
2. extractionthe mixture is extracted with dichloromethane (3×)
3. washThe combined organic phases are washed with water (3×)
4. dry with materialdried with sodium sulphate
5. concentrationconcentrated by evaporation