反应详情

温度

50 °C

To a solution of (4,5-difluoro-2-nitrophenyl)methanol (950 mg, 5 mmol) in DMF (15 mL) were added potassium carbonate (1.23 g, 10 mmol) and phenol (520 mg, 5.5 mmol). The resulting mixture was stirred at 50° C. overnight, cooled to room temperature, filtered, washed with ethyl acetate (2×20 mL), and concentrated. The resulting crude mixture was purified by chromatography (silica gel, 30-70% ethyl acetate in heptane) to yield a slightly yellow solid.

1. temperaturecooled to room temperature
2. filtrationfiltered
3. washwashed with ethyl acetate (2×20 mL)
4. concentrationconcentrated
5. customThe resulting crude mixture was purified by chromatography (silica gel, 30-70% ethyl acetate in heptane)
6. customto yield a slightly yellow solid