Hydrochloric Acid → HCID 23615038, compound

HRID 252478Notes

Reaction equation

HRID 252478 reaction equation
[CH3:1][C:2]1([CH3:30])[CH2:7][O:6][C:5]2([CH2:12][C:11]([CH3:14])([CH3:13])[N:10]([O:15][CH:16]([C:18]3[CH:23]=[CH:22][C:21]([O:24]C(=O)C)=[CH:20][CH:19]=3)[CH3:17])[C:9]([CH3:29])([CH3:28])[CH2:8]2)[O:4][CH2:3]1.C(=O)([O-])[O-].[K+].[K+].Cl>CO.O>[CH3:30][C:2]1([CH3:1])[CH2:7][O:6][C:5]2([CH2:8][C:9]([CH3:28])([CH3:29])[N:10]([O:15][CH:16]([C:18]3[CH:19]=[CH:20][C:21]([OH:24])=[CH:22][CH:23]=3)[CH3:17])[C:11]([CH3:14])([CH3:13])[CH2:12]2)[O:4][CH2:3]1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 58891832HCID 58891832, compound

Product 1

HCID 23615038HCID 23615038, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

A mixture of 8 g acetic acid 4-[1-(3,3,8,8,10,10-hexamethyl-1,5-dioxa-9-aza-spiro[5.5]undec-9-yloxy)-ethyl]-phenyl ester and 3.9 g potassium carbonate in 60 ml methanol is stirred for one hour at room temperature. The mixture is cooled to 0° C. and neutralized by adding 60 ml of 0.5 M hydrochloric acid. The white suspension is diluted with water (60 ml) and filtered through a buchner funnel. The residue is washed with water and dried in a vacuum oven at 50° C. A white solid having a melting point of 133-134° C. is obtained.

Workup

  1. temperatureThe mixture is cooled to 0° C.
  2. filtrationfiltered through a buchner funnel
  3. washThe residue is washed with water
  4. customdried in a vacuum oven at 50° C
  5. customis obtained

Sources & evidence

ORD record
ord-6f67ece400d84676b50c02ffc1cb3f1b
Source dataset
uspto-grants-2011_01
Patent number
US07868171B2

Reaction notes

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