Hydrochloric Acid → HCID 86620386, compound

HRID 252716Notes

Reaction equation

HRID 252716 reaction equation
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[S:12][C:11]([NH:13]C(=O)C)=[N:10][C:9]=2[CH3:17])=[CH:4][C:3]=1[NH:18][S:19]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)(=[O:21])=[O:20].Cl>>[NH2:13][C:11]1[S:12][C:8]([C:5]2[CH:4]=[C:3]([NH:18][S:19]([C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=3)(=[O:21])=[O:20])[C:2]([Cl:1])=[N:7][CH:6]=2)=[C:9]([CH3:17])[N:10]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 11541283HCID 11541283, compound

Product 1

HCID 86620386HCID 86620386, compound

Procedure

Using an analogous procedure to that described in Example 61, N-[5-(6-chloro-5-phenylsulfonylaminopyridin-3-yl)-4-methyl-1,3-thiazol-2-yl]acetamide was hydrolysed with aqueous hydrochloric acid solution to give the title compound; 1H NMR Spectrum: (DMSOd6) 2.11 (s, 3H), 7.24 (s, 2H), 7.50 (d, 1H), 7.60 (m, 2H), 7.68 (m, 1H), 7.77 (d, 2H), 8.14 (s, 1H), 10.42 (br s, 1H); Mass Spectrum: M+H+ 381.

Sources & evidence

ORD record
ord-3cd6d75d4699451399dc55f1a7d5e755
Source dataset
uspto-grants-2011_01
Patent number
US07868188B2

Reaction notes

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