反应详情

A mixture of 512 mg (4.0 mmol) of N,5-dimethylthiazol-2-amine, 352 mg (8.8 mmol, 60% strength in mineral oil) of sodium hydride and 2-bromoethylamine hydrobromide with DMF (10 ml) was stirred for 2 h at RT. The mixture was then poured into water and extracted with DCM. The organic phase was dried over MgSO4, filtered and evaporated under a vacuum. 232 mg (1.4 mmol, 34%) of N1-methyl-N1-(5-methylthiazol-2-yl)ethane-1,2-diamine were obtained by CC (DCM/EtOH/conc. aq. NH4—OH soln. 5:1:0.06) with the residue.

1. extractionextracted with DCM
2. dry with materialThe organic phase was dried over MgSO4
3. filtrationfiltered
4. customevaporated under a vacuum