1-Methylpiperazine → HCID 178480623, compound

HRID 252957Notes

Reaction equation

HRID 252957 reaction equation
C1(N2C(=O)C3=CNC4[CH:14]=[C:15]([N:19]5[CH2:24]CN[CH2:21][CH2:20]5)C=CC=4C3=N2)C=CC=CC=1.[NH2:27][C:28]1[CH:29]=[CH:30][C:31]2[C:32]3[C:33]([C:38](=[O:48])[N:39]([C:41]4[CH:46]=[CH:45][C:44]([Cl:47])=[CH:43][CH:42]=4)[N:40]=3)=[CH:34][NH:35][C:36]=2[CH:37]=1.CN1CCNCC1>>[Cl:47][C:44]1[CH:45]=[CH:46][C:41]([N:39]2[C:38](=[O:48])[C:33]3=[CH:34][NH:35][C:36]4[CH:37]=[C:28]([N:27]5[CH2:21][CH2:20][N:19]([CH3:24])[CH2:15][CH2:14]5)[CH:29]=[CH:30][C:31]=4[C:32]3=[N:40]2)=[CH:42][CH:43]=1

Participants

4

Reactant 3

HCID 531671-MethylpiperazineHCID 178507230HCID 178507230, compoundHCID 178515224HCID 178515224, compound

Product 1

HCID 178480623HCID 178480623, compound

Procedure

The title compound was prepared following the procedure for 14a using 13b and 1-methylpiperazine. 1H-NMR (CD3OD) δ (ppm): 2.39 (3H, s), 2.67 (4H, brm), 3.40 (4H, brm), 7.01 (1H, d, J=2.47 Hz), 7.34 (1H, dd, J=9.07, 2.47 Hz), 7.46 (2H, dd, J=6.87, 2.20 Hz), 8.09 (2H, dd, J=7.14, 1.92 Hz), 8.19 (1H, d, J=9.07 Hz), 8.51 (1H, s). m/z 394.9 (MH+).

Sources & evidence

ORD record
ord-09d1db64492e415db47956bc4c366872
Source dataset
uspto-grants-2011_01
Patent number
US07872002B2

Reaction notes

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