Piperidin-4-ol → HCID 178515223, compound

HRID 252969Notes

Reaction equation

HRID 252969 reaction equation
[F:1][C:2]1[C:11]([N:12]2[CH2:17][CH2:16]N[CH2:14][CH2:13]2)=[CH:10][C:9]2[NH:8][CH:7]=[C:6]3[C:18](=[O:27])[N:19]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)[N:20]=[C:5]3[C:4]=2[CH:3]=1.FC1C(F)=CC2C3C([C:39](=[O:48])N(C4C=CC=CC=4)N=3)=CNC=2C=1.OC1CCNCC1>>[F:1][C:2]1[C:11]([N:12]2[CH2:17][CH2:16][CH:39]([OH:48])[CH2:14][CH2:13]2)=[CH:10][C:9]2[NH:8][CH:7]=[C:6]3[C:18](=[O:27])[N:19]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)[N:20]=[C:5]3[C:4]=2[CH:3]=1

Participants

4

Reactant 3

HCID 79341Piperidin-4-olHCID 178515218HCID 178515218, compoundHCID 178515226HCID 178515226, compound

Product 1

HCID 178515223HCID 178515223, compound

Procedure

The title compound was prepared following the procedure described in the synthesis of 28a using 27a and 4-hydroxypiperidine. 1H-NMR (DMSO-d6) δ (ppm): 1.54 (2H, brm), 1.87 (2H, brm), 2.85 (2H, brm), 3.20 (1H, m), 3.64 (1H, brm), 4.74 (1H, brd, J=3.84 Hz), 7.10 (1H, m), 7.22 (1H, d, J=7.97 Hz), 7.40 (2H, m), 7.76 (1H, d, J=2.90 Hz), 8.20 (2H, m), 8.64 (1H, s). m/z 379.2 (MH+).

Sources & evidence

ORD record
ord-5d7d0b7b57cb49dda04b657e4191ef74
Source dataset
uspto-grants-2011_01
Patent number
US07872002B2

Reaction notes

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