反应详情

LiOH (2 N, 500 μL) was added to a solution of ethyl 1-acetyl-5-(cyclohexylmethyl)piperidine-3-carboxylate (180 mL, 0.61 mmol) in MeOH (1 mL) and THF (5 mL). After being maintained for two hours, the reaction was poured into a mixture of CH2Cl2 (25 mL) and H2O (10 mL). The layers were separated and the aqueous layer was extracted with CH2Cl2 (10 mL). The aqueous layer was acidified to pH 1 with 1N HCl and extracted with CH2Cl2 (3×20 mL). The combined organic layers were sequentially washed with H2O (10 mL) and brine before being dried over Na2SO4. Concentration under reduced pressure provided the title compound as a colorless oil. MS m/z: 268.0 (M+1).

1. temperatureAfter being maintained for two hours
2. customThe layers were separated
3. extractionthe aqueous layer was extracted with CH2Cl2 (10 mL)
4. extractionextracted with CH2Cl2 (3×20 mL)
5. washThe combined organic layers were sequentially washed with H2O (10 mL) and brine
6. dry with materialbefore being dried over Na2SO4
7. concentrationConcentration under reduced pressure