反应详情

A mixture of 9.4 g of 2-chloro-4-methyl-5-mercaptoaniline, 20 g of 2,2,2-trifluoroethyl iodide, 13 g of potassium carbonate and 200 ml of N,N-dimethylformamide was stirred at room temperature for 16 hours. The reaction mixture was concentrated under reduced pressure, water was added, and the mixture was extracted with toluene. The organic layer was washed with water and dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure to obtain 13.5 g of 2-chloro-4-methyl-5-(2,2,2-trifluoroethylthio)aniline.

1. concentrationThe reaction mixture was concentrated under reduced pressure, water
2. additionwas added
3. extractionthe mixture was extracted with toluene
4. washThe organic layer was washed with water
5. dry with materialdried over anhydrous magnesium sulfate
6. distillationthe solvent was distilled off under reduced pressure