反应详情

To 1,000 ml of a N,N-dimethylformamide solution of 129 g of 2-fluoro-4-methyl-5-mercaptoaniline, 250 g of 2,2,2-trifluoroethyl iodide and 125 g of potassium carbonate were added, and 10 g of Rongalit was further added, followed by stirring at room temperature for 8 hours. The reaction liquid was poured into water, the mixture was extracted with ethyl acetate, the organic layer was dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure to obtain 182 g of 2-fluoro-4-methyl-5-(2,2,2-trifluoroethylthio)aniline.

1. customThe reaction liquid
2. extractionthe mixture was extracted with ethyl acetate
3. dry with materialthe organic layer was dried over anhydrous magnesium sulfate
4. distillationthe solvent was distilled off under reduced pressure