反应详情

A mixture of 3-[(3-benzyloxy-2-methyl-phenyl)-methoxy-methyl]-1H-pyrrolo[2,3-b]pyridine (60, 24 mg, 0.067 mmol), trifluoroacetic acid (1 mL, 13 mmol), and triethylsilane (2 ml, 12.5 mmol) in acetonitrile (10 mL) was refluxed for 4 hours. The mixture was concentrated and the residue was dissolved in ethyl acetate. The solution was washed with saturated sodium bicarbonate, brine, and dried over sodium sulfate. After removal of solvent, the residue was washed with a mixture of ethyl ether and hexanes (1:1) to provide the compound as a yellow solid (P-1857, 17 mg, 75%). MS (ESI) [M+H+]+=329.24.

1. temperaturewas refluxed for 4 hours
2. concentrationThe mixture was concentrated
3. dissolutionthe residue was dissolved in ethyl acetate
4. washThe solution was washed with saturated sodium bicarbonate, brine
5. dry with materialdried over sodium sulfate
6. customAfter removal of solvent
7. washthe residue was washed with a mixture of ethyl ether and hexanes (1:1)