反应详情

温度

40 °C

To a mixture of 3-benzyloxy-2-hydroxy-benzaldehyde (129, 1.0 g, 4.38 mmol) and cesium carbonate (2.14 g, 6.57 mmol) in N,N-dimethylformamide (50 mL), cyclopropylmethyl bromide (1.77 g, 13.1 mmol) was added at room temperature. The mixture was stirred at 40° C. for 3 days. The reaction mixture was poured into a solution of saturated ammonium chloride and was extracted with ethyl acetate. The organic layer was collected, washed with brine, and dried over magnesium sulfate. After removal of solvent, a viscous liquid was obtained (130, 1.21 g, 98%).

1. additionwas added at room temperature
2. extractionwas extracted with ethyl acetate
3. customThe organic layer was collected
4. washwashed with brine
5. dry with materialdried over magnesium sulfate
6. customAfter removal of solvent
7. customa viscous liquid was obtained (130, 1.21 g, 98%)