反应详情

Methyl hexaethylene glycol (1.0 g, 3.37 mmol) and tert-butyl acrylate (0.216 g, 1.69 mmol) were dissolved in dry THF (10 mL). Sodium metal 0.4 mg, 0.016 mmol) was added to the solution. After stirring for 4 h at room temperature, the reaction mixture was quenched by the addition of 1 M HCl (15 mL). The quenched reaction mixture was then extracted with CH2Cl2 (1×50 mL, 1×25 mL). The organic layer was dried (MgSO4) and concentrated. After purification by silica gel chromatography (ethyl acetate as eluent), the product was obtained as an oil (0.832 g, 58%).

1. customthe reaction mixture was quenched by the addition of 1 M HCl (15 mL)
2. customThe quenched reaction mixture
3. extractionwas then extracted with CH2Cl2 (1×50 mL, 1×25 mL)
4. dry with materialThe organic layer was dried (MgSO4)
5. concentrationconcentrated
6. customAfter purification by silica gel chromatography (ethyl acetate as eluent)