反应详情

温度

95 °C

Mixture of 6-hydroxyindan-1-one of the formula (11) (20 gm, 0.135 mol), potassium carbonate (40 gm, 0.289 mol), 1,4-dichlorobutane (80 ml, 0.73 mol) and tetrabutyl ammonium bromide (2 g) was stirred for 1-3 hrs at 95° C. then distilled off excess 1,4-dichloro butane, diluted with water (80 ml). The aqueous layer was extracted with ethyl acetate, and the extract was washed with water, dried and evaporated off under reduced pressure to dryness. The evaporation residue is purified by crystallization using isopropyl ether as a solvent gave 29.5 gm of novel 6-(4-CHLORO BUTOXY)-INDAN-1-ONE of the formula (3).

1. distillationthen distilled off excess 1,4-dichloro butane
2. additiondiluted with water (80 ml)
3. extractionThe aqueous layer was extracted with ethyl acetate
4. washthe extract was washed with water
5. customdried
6. customevaporated off under reduced pressure to dryness
7. customThe evaporation residue is purified by crystallization