反应详情

温度

65 °C

A mixture of 6-hydroxyindan-1-one (100 gm, 0.675 mol), potassium carbonate (96 gm, 0.695 mol), 1,4-dibromo butane (365 gm, 1.69 mol) and tetrabutyl ammonium bromide in acetone was introduced in to a three necked round bottomed flask filtered with a water condenser and a mechanical stirrer. The mixture was brought to a temperature 65° C. and maintained at 65° C. for nine hours and then distilled off solvent, diluted with water (400 ml). The aqueous layer was extracted with ethyl acetate, and the extract was washed with water, dried and evaporated in the rotavapour under reduced pressure to get a residue which on crystallization from isopropyl ether gave 125 gm of 6-(4-bromo butoxy)-indan-1-one of the formula 3

1. additionwas introduced in to a three necked round bottomed flask
2. filtrationfiltered with a water condenser and a mechanical stirrer
3. customwas brought to a temperature 65° C.
4. distillationdistilled off solvent
5. additiondiluted with water (400 ml)
6. extractionThe aqueous layer was extracted with ethyl acetate
7. washthe extract was washed with water
8. customdried
9. customevaporated in the rotavapour under reduced pressure
10. customto get a residue which
11. customon crystallization from isopropyl ether