Hydrochloric Acid → HCID 178482379, compound

HRID 254231Notes

Reaction equation

HRID 254231 reaction equation
C(OC(=O)[NH:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([CH2:14][CH2:15][N:16]2[CH2:21][CH2:20][N:19]([C:22]3[C:27]([Cl:28])=[C:26]([Cl:29])[N:25]=[C:24]([NH:30][CH3:31])[N:23]=3)[CH2:18][CH2:17]2)[CH2:10][CH2:9]1)(C)(C)C.[ClH:33]>C(OC(=O)C)C>[ClH:28].[ClH:33].[ClH:28].[NH2:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([CH2:14][CH2:15][N:16]2[CH2:17][CH2:18][N:19]([C:22]3[C:27]([Cl:28])=[C:26]([Cl:29])[N:25]=[C:24]([NH:30][CH3:31])[N:23]=3)[CH2:20][CH2:21]2)[CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178482382HCID 178482382, compound

Product 1

HCID 178482379HCID 178482379, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

4.88 g (10 mmol) trans-(4-{2-[4-(5,6-dichloro-2-methylamino-pyrimidin-4-yl)-piperazin-1-yl]-ethyl}-cyclohexyl)-carbamic acid tert-butyl ester was deprotected at 10° C. using 100 ml ethylacetate saturated with gaseous hydrochloric acid. After 4 hours the precipitate was filtered giving the title compound (4.9 g, 99%), melting at 325-326° C.

Workup

  1. customwas deprotected at 10° C.
  2. filtrationAfter 4 hours the precipitate was filtered

Sources & evidence

ORD record
ord-5367f9de7a484ac991cc08a808bdbb8f
Source dataset
uspto-grants-2011_01
Patent number
US07875610B2

Reaction notes

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