Piperidine → HCID 178437604, compound

HRID 254281Notes

Reaction equation

HRID 254281 reaction equation
[CH2:1]([C:3]1[NH:4][C:5]([C:9]2[CH:14]=[C:13](F)[CH:12]=[CH:11][C:10]=2[N+:16]([O-:18])=[O:17])=[C:6]([CH3:8])[N:7]=1)[CH3:2].[NH:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1>C(OC(=O)C)C>[CH2:1]([C:3]1[NH:4][C:5]([C:9]2[CH:14]=[C:13]([N:19]3[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]3)[CH:12]=[CH:11][C:10]=2[N+:16]([O-:18])=[O:17])=[C:6]([CH3:8])[N:7]=1)[CH3:2]

Participants

4

Reactant 2

HCID 8082PiperidineHCID 178437603HCID 178437603, compound

Product 1

HCID 178437604HCID 178437604, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

5 g 2-(2-Ethyl-4-methyl-imidazolyl)-4-fluoro-nitrobenzene and 10 g piperidine were heated 30 minutes at 100° C. After cooling 150 ml ethylacetate were added. The solution was extracted three times with 50 ml water. The organic layer was evaporated to dryness. The residue is purified by chromatography (silica gel, dichloromethane/methanol=95/5).

Workup

  1. additionwere added
  2. extractionThe solution was extracted three times with 50 ml water
  3. customThe organic layer was evaporated to dryness
  4. customThe residue is purified by chromatography (silica gel, dichloromethane/methanol=95/5)

Sources & evidence

ORD record
ord-666a2c3983894c2184fe8740c8e478be
Source dataset
uspto-grants-2011_01
Patent number
US07875618B2

Reaction notes

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