Potassium Carbonate → HCID 59321321, compound

HRID 254282Notes

Reaction equation

HRID 254282 reaction equation
F[C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[CH:12]1([C:18]2[NH:19][CH:20]=[C:21]([CH3:23])[N:22]=2)[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[CH:12]1([C:18]2[N:19]([C:2]3[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=3[N+:9]([O-:11])=[O:10])[CH:20]=[C:21]([CH3:23])[N:22]=2)[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 679672,4-DifluoronitrobenzeneHCID 178430842HCID 178430842, compound

Product 1

HCID 59321321HCID 59321321, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

15.9 g (0.1 mol) 2,4-Difluoro-nitrobenzene, 16.5 g 2-Cyclohexyl-4-methylimidazole, 30 g potassium carbonate, and 150 ml acetonitrile were heated 24 hours at 60° C. After cooling the product was filtered off, washed with 100 ml acetonitrile, evaporated to dryness and chromatographed on silica gel with 5% MeOH/CH2Cl2.

Workup

  1. temperatureAfter cooling the product
  2. filtrationwas filtered off
  3. washwashed with 100 ml acetonitrile
  4. customevaporated to dryness
  5. customchromatographed on silica gel with 5% MeOH/CH2Cl2

Sources & evidence

ORD record
ord-c1fcc5a2f58043c3bbd7786ce7001a75
Source dataset
uspto-grants-2011_01
Patent number
US07875618B2

Reaction notes

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