Water → HCID 66863032, compound

HRID 254288Notes

Reaction equation

HRID 254288 reaction equation
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([N:9]2[CH:13]=[C:12]([CH3:14])[N:11]=[C:10]2[CH:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)[CH:3]=1.[C:21](N1C=CN=C1)(N1C=CN=C1)=[O:22].O>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[C:4]2[C:5]([NH:6][C:21](=[O:22])[C:13]3[N:9]2[C:10]([CH:15]2[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]2)=[N:11][C:12]=3[CH3:14])=[CH:7][CH:8]=1

Participants

5

Reactant 3

HCID 962WaterHCID 682631,1'-CarbonyldiimidazoleHCID 66862546HCID 66862546, compound

Product 1

HCID 66863032HCID 66863032, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

1.45 g 4-Chloro-2-(2-cyclohexyl-4-methyl-imidazol-1-yl)-aniline were stirred in 25 ml toluene. 1.0 g Carbonyldiimidazole was added and the mixture was refluxed for 6 hours. After cooling 25 ml water was added, the product was filtered off, washed with 20 ml water and 25 ml toluene and dried.

Workup

  1. temperaturethe mixture was refluxed for 6 hours
  2. additionwas added
  3. filtrationthe product was filtered off
  4. washwashed with 20 ml water and 25 ml toluene
  5. customdried

Sources & evidence

ORD record
ord-2c64572a5c214b5ab685f552e054d88e
Source dataset
uspto-grants-2011_01
Patent number
US07875618B2

Reaction notes

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