反应详情

温度

90 °C

2-bromo-4-methyl imidazole (3.7 g, 23.4 mmol) and 2-fluoro-6-methoxy-nitrobenzene were dissolved in DMF (80 mL). To this was then added potassium carbonate (6.3 g, 46.8 mmol). The reaction was heated to 90° C. for 16 hrs then poured into water and extracted with ethyl acetate. The organic layer was separated and washed with water then brined, dried over magnesium sulfate and filtered. The solvent was removed under reduced pressure and the crude purified by flash chromatography on silica gel in 20:1 ethyl acetate/methylene chloride. A tan solid (2.6 g) was recovered. MS (ES) m/z 311.9 [M+1]+

1. extractionextracted with ethyl acetate
2. customThe organic layer was separated
3. washwashed with water
4. dry with materialdried over magnesium sulfate
5. filtrationfiltered
6. customThe solvent was removed under reduced pressure
7. customthe crude purified by flash chromatography on silica gel in 20:1 ethyl acetate/methylene chloride
8. customA tan solid (2.6 g) was recovered