反应详情

温度

100 °C

A mixture of 2-chloroaniline (13.2 ml, 0.125 mol), iodoacetone (26.6 g, 0.145 mol) and potassium carbonate (18.1 g, 0.13 mol) in DMF (200 ml) was heated under nitrogen at 100° C. overnight. After cooling to rt, water was added and the mixture extracted with ether (×3). The combined organic extracts were washed with water, dried (Na2SO4), filtered and concentrated. Flash chromatography (Heptane:EtOAc 80:20) afforded 16.0 g (70%) of the title compound as a brown liquid.

1. temperatureAfter cooling to rt
2. extractionthe mixture extracted with ether (×3)
3. washThe combined organic extracts were washed with water
4. dry with materialdried (Na2SO4)
5. filtrationfiltered
6. concentrationconcentrated