p-Toluenesulfonic acid → HCID 178448987, compound

HRID 254564Notes

Reaction equation

[Cl:1][C:2]1[C:9]([F:10])=[CH:8][CH:7]=[C:6]([F:11])[C:3]=1[CH:4]=O.[CH2:12]([NH2:16])[CH2:13][CH2:14][CH3:15].C1(C)C=CC(S(O)(=O)=O)=CC=1>>[CH2:12](/[N:16]=[CH:4]/[C:3]1[C:6]([F:11])=[CH:7][CH:8]=[C:9]([F:10])[C:2]=1[Cl:1])[CH2:13][CH2:14][CH3:15]

Participants

Reactant 3

HCID 6101p-Toluenesulfonic acid

HCID 8007Butylamine

HCID 27735092-Chloro-3,6-difluorobenzaldehyde

Product 1

HCID 178448987HCID 178448987, compound

Procedure

Butyl-[1-(2-chloro-3,6-difluoro-phenyl)-meth-(E)-ylidene]-amine was prepared from 2-chloro-3,6-difluorobenzaldehyde, N-butylamine and p-toluenesulphonic acid in analogy to Example 191a): yellow oil; MS (ISP): 234.1 ([M+H]+, 30%), 232.3 ([M+H]+, 100%).

Sources & evidence

ORD record: ord-3f29a09a77a44ddd9a298969c82bdc48
Source dataset: uspto-grants-2011_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07875645B2

Reaction notes

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