Trichloroisocyanuric Acid → 2-(3-Chloro-2-ethyl-6-fluoro-benzyl)-1H-imidazole

HRID 254577Notes

Reaction equation

HRID 254577 reaction equation
[Cl:1][C:2]1[C:3]([CH2:15][CH3:16])=[C:4]([C:11]([F:14])=[CH:12][CH:13]=1)[CH2:5][C:6]1[NH:7][CH2:8][CH2:9][N:10]=1.C1(N(Cl)C(=O)N(Cl)C(=O)N1Cl)=O.C1CCN2C(=NCCC2)CC1>>[Cl:1][C:2]1[C:3]([CH2:15][CH3:16])=[C:4]([C:11]([F:14])=[CH:12][CH:13]=1)[CH2:5][C:6]1[NH:10][CH:9]=[CH:8][N:7]=1

Participants

4

Reactant 3

HCID 6909Trichloroisocyanuric AcidHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 247798502-(3-Chloro-2-ethyl-6-fluoro-benzyl)-4,5-dihydro-1H-imidazole

Product 1

HCID 589517582-(3-Chloro-2-ethyl-6-fluoro-benzyl)-1H-imidazole

Procedure

2-(3-Chloro-2-ethyl-6-fluoro-benzyl)-1H-imidazole was prepared from 2-(3-chloro-2-ethyl-6-fluoro-benzyl)-4,5-dihydro-1H-imidazole (Example 198), TCCA and DBU in analogy to Example 194e): light yellow crystals; MS (ISP): 241.2 ([M+H]+, 58%), 239.2 ([M+H]+, 100%).

Sources & evidence

ORD record
ord-348278992a094d91904c1c1453a0cfa2
Source dataset
uspto-grants-2011_01
Patent number
US07875645B2

Reaction notes

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