Trichloroisocyanuric Acid → 2-(2-Ethyl-3,6-difluoro-benzyl)-1H-imidazole

HRID 254578Notes

Reaction equation

HRID 254578 reaction equation
[CH2:1]([C:3]1[C:14]([F:15])=[CH:13][CH:12]=[C:11]([F:16])[C:4]=1[CH2:5][C:6]1[NH:7][CH2:8][CH2:9][N:10]=1)[CH3:2].C1(N(Cl)C(=O)N(Cl)C(=O)N1Cl)=O.C1CCN2C(=NCCC2)CC1>>[CH2:1]([C:3]1[C:14]([F:15])=[CH:13][CH:12]=[C:11]([F:16])[C:4]=1[CH2:5][C:6]1[NH:10][CH:9]=[CH:8][N:7]=1)[CH3:2]

Participants

4

Reactant 3

HCID 6909Trichloroisocyanuric AcidHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 589517482-(2-Ethyl-3,6-difluoro-benzyl)-4,5-dihydro-1H-imidazole

Product 1

HCID 589519032-(2-Ethyl-3,6-difluoro-benzyl)-1H-imidazole

Procedure

2-(2-Ethyl-3,6-difluoro-benzyl)-1H-imidazole was prepared from 2-(2-ethyl-3,6-difluoro-benzyl)-4,5-dihydro-1H-imidazole (Example 199), TCCA and DBU in analogy to Example 194e): light yellow crystals; MS (ISP): 223.3 ([M+H]+, 100%).

Sources & evidence

ORD record
ord-c6c090c1521145b6b0c9d434f473af87
Source dataset
uspto-grants-2011_01
Patent number
US07875645B2

Reaction notes

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