Trifluoroacetic acid → HCID 24779982, compound

HRID 254593Notes

Reaction equation

HRID 254593 reaction equation
[CH2:1]([O:3][C:4]1[CH:9]=[C:8]([CH2:10][CH3:11])[C:7]([CH:12]([C:14]2[NH:15][CH:16]=[CH:17][N:18]=2)O)=[C:6]([CH2:19][CH3:20])[CH:5]=1)[CH3:2].C([SiH](CC)CC)C.FC(F)(F)C(O)=O>>[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH2:19][CH3:20])[C:7]([CH2:12][C:14]2[NH:15][CH:16]=[CH:17][N:18]=2)=[C:8]([CH2:10][CH3:11])[CH:9]=1)[CH3:2]

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 12052TriethylsilaneHCID 58951836HCID 58951836, compound

Product 1

HCID 24779982HCID 24779982, compound

Procedure

2-(4-Ethoxy-2,6-diethyl-benzyl)-1H-imidazole was prepared from rac-(4-ethoxy-2,6-diethyl-phenyl)-(1H-imidazol-2-yl)-methanol, triethylsilane and trifluoroacetic acid in analogy to Example 191e): light yellow crystals; MS (ISP): 259.4 ([M+H]+, 100%).

Sources & evidence

ORD record
ord-96ce989954ce4d8696f4cc0bf9d5553d
Source dataset
uspto-grants-2011_01
Patent number
US07875645B2

Reaction notes

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