Trifluoroacetic acid → HCID 24779984, compound

HRID 254598Notes

Reaction equation

HRID 254598 reaction equation
[CH2:1]([O:8][C:9]1[C:10]([CH2:24][CH3:25])=[C:11]([CH:17]([C:19]2[NH:20][CH:21]=[CH:22][N:23]=2)O)[C:12]([CH2:15][CH3:16])=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C([SiH](CC)CC)C.FC(F)(F)C(O)=O>>[CH2:1]([O:8][C:9]1[C:10]([CH2:24][CH3:25])=[C:11]([C:12]([CH2:15][CH3:16])=[CH:13][CH:14]=1)[CH2:17][C:19]1[NH:20][CH:21]=[CH:22][N:23]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 12052TriethylsilaneHCID 58951822HCID 58951822, compound

Product 1

HCID 24779984HCID 24779984, compound

Procedure

2-(3-Benzyloxy-2,6-diethyl-benzyl)-1H-imidazole was prepared from rac-(3-benzyloxy-2,6-diethyl-phenyl)-(1H-imidazol-2-yl)-methanol, triethylsilane and trifluoroacetic acid in analogy to Example 191e): off-white crystals; MS (ISP): 321.0 ([M+H]+, 100%).

Sources & evidence

ORD record
ord-47bfdad19ad24545b7ce0bfb2ddc857e
Source dataset
uspto-grants-2011_01
Patent number
US07875645B2

Reaction notes

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