Trifluoroacetic acid → HCID 24779847, compound

HRID 254602Notes

Reaction equation

HRID 254602 reaction equation
[CH2:1]([C:3]1[C:8]([O:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:7][CH:6]=[C:5]([CH2:16][CH3:17])[C:4]=1[CH:18]([C:20]1[NH:21][CH:22]=[CH:23][N:24]=1)O)[CH3:2].C([SiH](CC)CC)C.FC(F)(F)C(O)=O>>[CH2:1]([C:3]1[C:8]([O:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:7][CH:6]=[C:5]([CH2:16][CH3:17])[C:4]=1[CH2:18][C:20]1[NH:24][CH:23]=[CH:22][N:21]=1)[CH3:2]

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 12052TriethylsilaneHCID 58951781HCID 58951781, compound

Product 1

HCID 24779847HCID 24779847, compound

Procedure

2-(2,6-Diethyl-3-phenoxy-benzyl)-1H-imidazole was prepared from rac-(2,6-diethyl-3-phenoxy-phenyl)-(1H-imidazol-2-yl)-methanol, triethylsilane and trifluoroacetic acid in analogy to Example 191e): white crystals; MS (ISP): 307.3 ([M+H]+, 100%).

Sources & evidence

ORD record
ord-487a7f72861d41d59213b19400076af5
Source dataset
uspto-grants-2011_01
Patent number
US07875645B2

Reaction notes

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