Trifluoroacetic acid → HCID 58951716, compound

HRID 254603Notes

Reaction equation

HRID 254603 reaction equation
[NH:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH:6]([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=2)[CH:9]=1)O.C([SiH](CC)CC)C.FC(F)(F)C(O)=O>>[NH:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH2:6][C:8]1[CH:9]=[C:10]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=2)[CH:11]=[CH:12][CH:13]=1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 12052TriethylsilaneHCID 58951847HCID 58951847, compound

Product 1

HCID 58951716HCID 58951716, compound

Procedure

2-[3-(1H-Imidazol-2-ylmethyl)-phenyl]-pyridine was prepared from rac-(1H-imidazol-2-yl)-(3-pyridin-2-yl-phenyl)-methanol, triethylsilane and trifluoroacetic acid in analogy to Example 191e): white crystals; MS (ISP): 236.3 ([M+H]+, 100%).

Sources & evidence

ORD record
ord-71ba47e6a361484c9006f3b8b3ab01ed
Source dataset
uspto-grants-2011_01
Patent number
US07875645B2

Reaction notes

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