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HRID254842

反应详情

EQUATION

反应方程式

HRID 254842 的结构方程式

REACTANTS

反应物

5
结构：OO
HCID784

Hydrogen peroxide

H2O2

结构：CC(=O)OO
HCID6585

Peracetic acid

C2H4O3

结构：COc1ccc2c3c1O[C@H]1C(=O)CC[C@@]4(O)[C@@H](C2)N(C)CC[C@]314
HCID5284603

Oxycodone

C18H21NO4

2 次

结构：COc1ccc2c3c1O[C@H]1C(=O)C=C[C@H]4[C@@H](C2)N(C)CC[C@]314
HCID5459910

Codeinone

C18H19NO3

结构：COC1=CC=C2[C@H]3Cc4ccc(OC)c5c4[C@@]2(CCN3C)[C@H]1O5.O=C([O-])C(O)C(O)C(=O)O
HCID131728625

未命名化合物

PRODUCTS

生成物

1
结构：COc1ccc2c3c1OC1C(=O)C=C[C@@]4(O)[C@@H](C2)N(C)CC[C@]314
HCID5359420

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：O=CO
溶剂HCID284

Formic acid

CH2O2

结构：CC(C)O
溶剂HCID3776

Isopropanol

C3H8O

PROCEDURE

实验过程

Oxycodone has also been prepared from thebaine bitartrate and codeinone ethyldienol ether by oxidation with hydrogen peroxide in formic acid and isopropanol, followed by catalytic hydrogenation5. Oxycodone has also been prepared by the oxidation with peracetic acid of codeinone dienol silylether in organic solvents to give 14-hydroxycodeinone, followed by catalytic hydrogenation in acetic acid solution15.