反应详情

3-{Ethoxycarbonylmethyl-[6-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoyl]-amino}-propionic acid ethyl ester AB (11.5 g, 21.3 mmol) is dissolved in 20% piperidine in dimethylformamide at 0° C. The solution is continued stirring for 1 h. The reaction mixture is concentrated under vacuum, water is added to the residue, and the product is extracted with ethyl acetate. The crude product is purified by conversion into its hydrochloride salt.

1. concentrationThe reaction mixture is concentrated under vacuum, water
2. additionis added to the residue
3. extractionthe product is extracted with ethyl acetate
4. customThe crude product is purified by conversion into its hydrochloride salt