反应详情

温度

85 °C

A mixture of 2-aminothiazole (15 g, 0.15 mol) and 2-bromoethyl methyl ether(17 mL, 0.18 mol) were heated at 85° C. for 16 hours. After cooling to ambient temperature the resulting solid was triturated twice with isopropyl alcohol and collected by filtration to afford 26 g (72%) of the title compound. 1H NMR (DMSO-d6, 300 MHz) δ ppm 3.27 (s, 3 H), 3.63 (t, J=5.1 Hz, 2 H), 4.23 (t, J=4.9 Hz, 2 H), 7.02 (d, J=4.7 Hz, 1 H), 7.38 (d, J=4.4 Hz, 1 H), 9.52 (s, 1H); MS (DCI/NH3) m/z 159 (M+H)+.

1. temperatureAfter cooling to ambient temperature the resulting solid
2. customwas triturated twice with isopropyl alcohol
3. filtrationcollected by filtration