2-Bromoethanol → HCID 66858594, compound

HRID 255093Notes

Reaction equation

HRID 255093 reaction equation
[CH2:1]=[C:2]1[C:6](=[CH2:7])[S:5][C:4]([NH2:8])=[N:3]1.[Br:9][CH2:10][CH2:11][OH:12]>>[BrH:9].[NH:8]=[C:4]1[N:3]([CH2:10][CH2:11][OH:12])[C:2]([CH3:1])=[C:6]([CH3:7])[S:5]1

Participants

3

Reactant 2

HCID 108982-BromoethanolHCID 91550098HCID 91550098, compound

Product 1

HCID 66858594HCID 66858594, compoundYield 47%

Procedure

A mixture of 4,5-dimethlyl-thiazol-2-ylamine (1.0 g, 7.8 mmol) and 2-bromoethanol (0.68 mL, 9.4 mmol) were processed as described in Example 8A to provide 0.92 g (47%) of the title compound 1H NMR (DMSO-d6, 300 MHz) δ ppm 2.19 (s, 6 H), 3.61-3.68 (m, 2 H), 4.03 (t, J=4.9 Hz, 2 H), 5.14 (brs, 1H) 9.27 (s, 1 H); MS (DCI/NH3) m/z 173 (M+H)+.

Sources & evidence

ORD record
ord-caadd72e94aa4d13af109335ab26839a
Source dataset
uspto-grants-2011_01
Patent number
US07875639B2

Reaction notes

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