2-Bromoethyl methyl ether → 5-(4,4-Difluorocyclohexyl)-3-(2-methoxyethyl)thiazol-2(3h)-imine hydrobromide

HRID 255145Notes

Reaction equation

HRID 255145 reaction equation
[F:1][C:2]1([F:14])[CH2:7][CH2:6][CH:5]([C:8]2[S:12][CH:11]([NH2:13])[NH:10][CH:9]=2)[CH2:4][CH2:3]1.[CH3:15][O:16][CH2:17][CH2:18][Br:19]>>[BrH:19].[F:14][C:2]1([F:1])[CH2:7][CH2:6][CH:5]([C:8]2[S:12][C:11](=[NH:13])[N:10]([CH2:18][CH2:17][O:16][CH3:15])[CH:9]=2)[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 809722-Bromoethyl methyl etherHCID 66859799HCID 66859799, compound

Product 1

HCID 668595395-(4,4-Difluorocyclohexyl)-3-(2-methoxyethyl)thiazol-2(3h)-imine hydrobromide

Procedure

A mixture of Example 184E and commercially available 2-bromoethyl methyl ether (Aldrich) was processed using the method described in Example 46A to afford the title compound. MS (ESI+) m/z 277 (M+H)+.

Sources & evidence

ORD record
ord-ef9079e2135f48609f982b9d3b7bbcc7
Source dataset
uspto-grants-2011_01
Patent number
US07875639B2

Reaction notes

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