HCID 178504227, compound → HCID 87181398, compound

HRID 255149Notes

Reaction equation

HRID 255149 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[S:13]/[C:12](=[N:14]\[C:15]([C:17]23[CH2:26][CH:21]4[CH2:22][CH:23]([CH2:25][CH:19]([CH2:20]4)[CH2:18]2)[CH2:24]3)=[O:16])/[N:11](COCC[Si](C)(C)C)[CH:10]=1>FC(F)(F)C(O)=O>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[S:13][C:12]([NH:14][C:15]([C:17]23[CH2:26][CH:21]4[CH2:20][CH:19]([CH2:25][CH:23]([CH2:22]4)[CH2:24]2)[CH2:18]3)=[O:16])=[N:11][CH:10]=1

Participants

3

Reactant 1

HCID 178504227HCID 178504227, compound

Product 1

HCID 87181398HCID 87181398, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of Example 200B in trifluoroacetic acid was heated at 50° C. for 3 hours then concentrated. The residue was diluted with saturated aqueous NaHCO3, and extracted with ethyl acetate. The organic extract was dried (Na2SO4), filtered and concentrated to afford the title compound MS (ESI) m/z 375 (M+H)+.

Workup

  1. concentrationthen concentrated
  2. additionThe residue was diluted with saturated aqueous NaHCO3
  3. extractionextracted with ethyl acetate
  4. extractionThe organic extract
  5. dry with materialwas dried (Na2SO4)
  6. filtrationfiltered
  7. concentrationconcentrated

Sources & evidence

ORD record
ord-2957036caca441e086cf3e705bdfb678
Source dataset
uspto-grants-2011_01
Patent number
US07875639B2

Reaction notes

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