Triethylamine → 7-Methoxy-3,4-dihydroquinolin-2(1H)-one

HRID 255185ノート

反応式

HRID 255185 の反応式
[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][C:8](=[O:12])[NH:9]2)=[CH:4][CH:3]=1.[CH2:13](N(CC)CC)C.C[Si](C=[N+]=[N-])(C)C>ClCCl.CO.C(#N)C>[CH3:13][O:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][C:8](=[O:12])[NH:9]2)=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 167693TrimethylsilyldiazomethaneHCID 27857587-Hydroxy-3,4-dihydrocarbostyril

生成物 1

HCID 128994187-Methoxy-3,4-dihydroquinolin-2(1H)-one収率 73%

試薬・触媒・溶媒 1

HCID 22226298HCID 22226298、化合物溶媒

実験手順

A mixture of 7-hydroxy-3,4-dihydroquinolin-2(1H)-one (3.0 g, 17 mmol) and triethyl amine (3.14 mL, 22 mmol) in dichloromethane/methanol/acetonitrile (10:1:10, 168 mL) was treated with (trimethylsilyl)diazomethane (2M solution in hexanes, 10.25 mL, 20.5 mmol). It was stirred over night at room temperature, the solvent was removed under reduced pressure and chromatography on silica gel with hexanes/acetone (1:1) gave 2.2 g (67%) of the product as a colorless solid.

後処理

  1. customthe solvent was removed under reduced pressure and chromatography on silica gel with hexanes/acetone (1:1)

出典と根拠

ORDレコード
ord-ce70ae46bc034020b05d60f45d7f6552
出典データセット
uspto-grants-2011_01
特許番号
US07875715B2

反応ノート

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