反应详情

A mixture of 5.0 g (0.013 mol) of product of Example 28, 3.42 g (0.034 mol) of triethylamine, 2.08 g (0.017 mol) of N-aminopyrrolidine hydrochloride in 30 ml of DMF were reacted at 45° C. for 1 hour. The reaction mixture was poured into water, extracted with ether, washed with diluted HCl, dried (MgSO4) and concentrated in vacuo to 4.06 g of light yellow solid. This solid was recrystallized in hot hexane affording 3.47 g (59.9%) of product as a beige solid; mp 101°-103° C.

1. customwere reacted at 45° C. for 1 hour
2. extractionextracted with ether
3. washwashed with diluted HCl
4. dry with materialdried (MgSO4)
5. concentrationconcentrated in vacuo to 4.06 g of light yellow solid
6. customThis solid was recrystallized in hot hexane affording 3.47 g (59.9%) of product as a beige solid