Pyrrolidine → HCID 14013802, compound

HRID 255419Notes

Reaction equation

HRID 255419 reaction equation
[F:1][C:2]([F:24])([F:23])[C:3]1[C:8]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[C:7](Cl)[C:6]([C:15]([O:17][CH3:18])=[O:16])=[C:5]([C:19]([F:22])([F:21])[F:20])[N:4]=1.[NH:25]1[CH2:29][CH2:28][CH2:27][CH2:26]1>CN(C=O)C>[N:25]1([C:7]2[C:6]([C:15]([O:17][CH3:18])=[O:16])=[C:5]([C:19]([F:22])([F:20])[F:21])[N:4]=[C:3]([C:2]([F:1])([F:24])[F:23])[C:8]=2[C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH2:29][CH2:28][CH2:27][CH2:26]1

Participants

4

Reactant 2

HCID 31268PyrrolidineHCID 14013761HCID 14013761, compound

Product 1

HCID 14013802HCID 14013802, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

This compound was prepared as described in Example 37: 6.0 g (0.016 mol) of product of Example 27, 2.6 ml (0.032 mol) of pyrrolidine in 30 ml of DMF were reacted affording a brown solid which was recrystallized in hot hexane giving 5.18 g (78.1%) of product as a tan solid; mp 68.5°-70° C.

Workup

  1. customThis compound was prepared
  2. customaffording a brown solid which
  3. customwas recrystallized in hot hexane giving 5.18 g (78.1%) of product as a tan solid

Sources & evidence

ORD record
ord-7d6dbffbe26145248146a39bb767217e
Source dataset
uspto-grants-1987_10
Patent number
US04698093

Reaction notes

Loading…