Hydrochloric Acid → HCID 178477822, compound

HRID 255496Notes

Reaction equation

HRID 255496 reaction equation
[C:1]([C:3]1[O:4][C:5]2[C:14]3[N:13]=[CH:12][CH:11]=[CH:10][C:9]=3[C:8]([Cl:15])=[CH:7][C:6]=2[N:16]=1)#[N:2].[N-:17]=[N+:18]=[N-:19].[Na+].[Cl-].[NH4+].Cl>CN(C=O)C.O>[NH:17]1[C:1]([C:3]2[O:4][C:5]3[C:14]4[N:13]=[CH:12][CH:11]=[CH:10][C:9]=4[C:8]([Cl:15])=[CH:7][C:6]=3[N:16]=2)=[N:2][N:19]=[N:18]1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 25517Ammonium ChlorideHCID 33557Sodium AzideHCID 134728705-Chloro[1,3]oxazolo[4,5-h]quinoline-2-carbonitrile

Product 1

HCID 178477822HCID 178477822, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Conditions

Temperature
120 °C

Procedure

A mixture of 5 g of 2-cyano-5-chloro-1,3-oxazolo-[4,5-h]quinoline and 1.0 g of sodium azide and 2 g of ammonium chloride in 100 ml of DMF are heated for 3 hours at 120° C. The reaction mixture is poured into water acidified with dilute HCl, and the product is filtered and recrystallized.

Workup

  1. filtrationthe product is filtered
  2. customrecrystallized

Sources & evidence

ORD record
ord-032af8ad63fd428595d23a19e327a9ca
Source dataset
uspto-grants-1987_10
Patent number
US04698346

Reaction notes

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