反应详情

Meanwhile, 5 ml of 6N hydrogen chloride/dioxane were added to 152 mg (0.5 mmole) of ethyl 4(S)-t-butoxycarbonylamino-3(S)-hydroxy-6-methylheptanoate. The solution was stirred for 20 minutes under a nitrogen stream, and then concentrated by evaporation under reduced pressure, to give a solid residue. The resulting residue was dissolved in 2 ml of dimethylformamide, and 0.05 g of N-methylmorpholine was added to give a solution of ethyl 4(S)-amino-3(S)-hydroxy-6-methylheptanoate.

1. concentrationconcentrated by evaporation under reduced pressure
2. customto give a solid residue