反应详情

温度

100 °C

In 15 ml of N,N-dimethylformamide was dissolved 0.4 g of 6-(4-dimethylaminophenyl)-1-(4-hydroxyphenyl)-4-oxo-1,4-dihydronicotinic acid at room temperature, and to this solution was added 0.33 g of potassium carbonate. The resulting mixture was heated to 100° C. for 1 hour. The reaction mixture thus obtained was cooled to room temperature, and 0.2 g of methoxymethyl chloride was added thereto. The resulting mixture was subjected to reaction at room temperature for 1 hour. After completion of this reaction, the solvent was removed by distillation under reduced pressure, and the residue was purified by a column chromatography (Wako Silica Gel C-200; eluent: chloroform/ethanol (30:1 by volume) mixture) to obtain 0.16 g of methoxymethyl 6-(4-dimethylaminophenyl)-1-(4-methoxymethyloxyphenyl)-4-oxo-1,4-dihydronicotinate having a melting point of 199°-201° C. and 0.13 g of methoxymethyl 6-(4-dimethylaminophenyl)-1-(4-hydroxyphenyl)-4-oxo-1,4-dihydronicotinate having a melting point of 211°-213° C.

1. customThe reaction mixture thus obtained
2. temperaturewas cooled to room temperature
3. customThe resulting mixture was subjected to reaction at room temperature for 1 hour
4. customAfter completion of this reaction
5. customthe solvent was removed by distillation under reduced pressure
6. customthe residue was purified by a column chromatography (Wako Silica Gel C-200; eluent: chloroform/ethanol (30:1 by volume) mixture)