Phosphorus oxychloride → HCID 13986496, compound

HRID 255701Notes

Reaction equation

HRID 255701 reaction equation
[Cl:1][C:2]1[CH:24]=[CH:23][CH:22]=[CH:21][C:3]=1[C:4]([NH:6][C:7]1[C:8]([N:13]([CH3:20])[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[N:9][CH:10]=[CH:11][CH:12]=1)=O.P(Cl)(Cl)(Cl)=O>>[Cl:1][C:2]1[CH:24]=[CH:23][CH:22]=[CH:21][C:3]=1[C:4]1[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=2[N:13]([CH3:20])[C:8]2[N:9]=[CH:10][CH:11]=[CH:12][C:7]=2[N:6]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 135601862-Chloro-N-{2-[methyl(phenyl)amino]pyridin-3-yl}benzamide

Product 1

HCID 13986496HCID 13986496, compound

Procedure

Following the procedure of Example 58, 2-chloro-N-[2-(methylphenylamino)-3-pyridinyl]benzamide was cyclized to the title compound with phosphorus oxychloride and isolated, recrystallizing from isopropyl alcohol as yellow solid, m.p. 131.5°-133° C.

Sources & evidence

ORD record
ord-ea92c5b1c201434aa95ab131c23fc83e
Source dataset
uspto-grants-1987_10
Patent number
US04698430

Reaction notes

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